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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "pmxNODE" in publications use:'
type: software
license: GPL-3.0-or-later
title: 'pmxNODE: Application of NODEs in ''Monolix'', ''NONMEM'', and ''nlmixr2'''
version: 0.1.0
doi: 10.1002/psp4.13265
identifiers:
- type: doi
  value: 10.32614/CRAN.package.pmxNODE
abstract: An easy-to-use tool for implementing Neural Ordinary Differential Equations
  (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see
  Bräm et al. (2024) <https://doi.org/10.1007/s10928-023-09886-4> and Bräm et al.
  (2025) <https://doi.org/10.1002/psp4.13265>. The main functionality is to automatically
  generate structural model code describing computations within a neural network.
  Additionally, parameters and software settings can be initialized automatically.
  For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces
  with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package
  is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>)
  and is not available from public repositories.
authors:
- family-names: Bräm
  given-names: Dominic
  email: domi.braem@hotmail.com
  orcid: https://orcid.org/0000-0001-9094-8361
preferred-citation:
  type: article
  title: Low-dimensional neural ordinary differential equations accounting for inter-individual
    variability implemented in Monolix and NONMEM
  authors:
  - family-names: Bräm
    given-names: Dominic S.
  - family-names: Steiert
    given-names: Bernhard
  - family-names: Pfister
    given-names: Marc
  - family-names: Steffens
    given-names: Britta
  - family-names: Koch
    given-names: Gilbert
  journal: 'CPT: Pharmacometrics & Systems Pharmacology'
  year: '2024'
  url: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1002/psp4.13265
  doi: 10.1002/psp4.13265
  start: '1'
  end: '12'
repository: https://braemd.r-universe.dev
repository-code: https://github.com/braemd/pmxNODE
commit: a0bcd7019180c2bf619f119739972b21216024c0
url: https://github.com/braemd/pmxNODE
date-released: '2025-11-19'
contact:
- family-names: Bräm
  given-names: Dominic
  email: domi.braem@hotmail.com
  orcid: https://orcid.org/0000-0001-9094-8361
references:
- type: article
  title: Low-dimensional neural ODEs and their application in pharmacokinetics
  authors:
  - family-names: Bräm
    given-names: Dominic S.
  - family-names: Nahum
    given-names: Uri
  - family-names: Schropp
    given-names: Johannes
  - family-names: Pfister
    given-names: Marc
  - family-names: Koch
    given-names: Gilbert
  journal: Journal of Pharmacokinetics and Pharmacodynamics
  year: '2024'
  volume: '51'
  url: https://doi.org/10.1007/s10928-023-09886-4
  doi: 10.1007/s10928-023-09886-4
  start: '123'
  end: '140'