Package: pmxNODE
Type: Package
Title: Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'
Version: 0.2.1
Authors@R: c(person("Dominic", "Bräm", role = c("aut", "cre"),
    email = "domi.braem@hotmail.com", comment = c(ORCID = "0000-0001-9094-8361")),
    person("Bernhard", "Steiert", role = c("ctb")),
    person("Gilbert", "Koch", role = c("ctb")),
    person("Matthew","Fidler", role = c("ctb"), comment=c(ORCID="0000-0001-8538-6691")))
Description: An easy-to-use tool for implementing Neural Ordinary
        Differential Equations (NODEs) in pharmacometric software such
        as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024)
        <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025)
        <doi:10.1002/psp4.13265>. The main functionality is to
        automatically generate structural model code describing
        computations within a neural network. Additionally, parameters
        and software settings can be initialized automatically. For
        using these additional functionalities with 'Monolix',
        'pmxNODE' interfaces with 'MonolixSuite' via the
        'lixoftConnectors' package. The 'lixoftConnectors' package is
        distributed with 'MonolixSuite'
        (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>)
        and is not available from public repositories.
License: GPL (>= 3)
Encoding: UTF-8
Suggests: rxode2, nlmixr2, lixoftConnectors, withr, testthat (>=
        3.0.0), knitr, rmarkdown
Imports: tidyr, ggplot2, checkmate
Config/testthat/edition: 3
BugReports: https://github.com/braemd/pmxNODE/issues
VignetteBuilder: knitr
Config/roxygen2/version: 8.1.0
Config/pak/sysreqs: libicu-dev
Repository: https://braemd.r-universe.dev
Date/Publication: 2026-09-23 11:11:21 UTC
RemoteUrl: https://github.com/braemd/pmxnode
RemoteRef: HEAD
RemoteSha: c341d3d8f13d2f9459f9a7a12a0cc6d57fe4831a
NeedsCompilation: no
Packaged: 2026-10-23 11:22:47 UTC; root
Author: Dominic Bräm [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-9094-8361>),
  Bernhard Steiert [ctb],
  Gilbert Koch [ctb],
  Matthew Fidler [ctb] (ORCID: <https://orcid.org/0000-0001-8538-6691>)
Maintainer: Dominic Bräm <domi.braem@hotmail.com>